AngE by SOT Medical: non-invasive screening for peripheral artery disease
Medically reviewed by Pharmacist Cherlyn
The short answer
AngE by SOT Medical is a non-invasive vascular screening system that detects peripheral artery disease (PAD) in about a minute, using ankle and toe pressures, pulse volume recordings, and optical sensors. A 2025 Biomedicines study showed its forefoot pulse-volume reading can find PAD in the diabetic foot even when the standard ankle-brachial index test reads falsely normal (96.8% sensitivity).
AngE by SOT Medical Systems — an Austrian company that has developed vascular diagnostics since 1999 — is a non-invasive system for spotting peripheral artery disease (PAD) and circulation problems quickly, in everyday clinical settings. CityMedic distributes it in Malaysia.
Why peripheral artery disease matters
PAD is the narrowing of the arteries that feed your legs, driven by the same atherosclerosis behind heart attacks and strokes. It's common in people who are older, smoke, or live with diabetes — and it's frequently silent until it causes leg pain, slow-healing wounds, or, at worst, a diabetic foot ulcer that threatens the limb. Catching it early changes outcomes.
How AngE screens — in about a minute
AngE is non-invasive and automated enough to be delegated to a nurse or technician. Depending on the configuration it can measure:
- Ankle-Brachial Index (ABI) and Toe-Brachial Index (TBI) — pressure comparisons that flag arterial narrowing.
- Pulse Volume Recording (PVR) and segmental oscillography — the shape and size of the pulse along the limb.
- Toe and forefoot optical sensors (photoplethysmography) for circulation at the far end of the foot.
It comes in modules — AngE ABI+ (arterial screening), AngE DIABETIC (built for the diabetic foot, measuring several sites at once), AngE Phlebo (venous testing), and AngE COMPLETE (arterial + venous) — and summarises results into an easy-to-read vascular health score.
The diabetic-foot problem AngE is built to solve
Here's the catch with diabetes: it often calcifies the leg arteries (medial arterial calcification), which makes them stiff and incompressible. That causes the standard ABI test to read falsely normal — or even high — hiding real, dangerous disease in exactly the patients most at risk of foot ulcers and amputation. A test that still works in this situation is genuinely valuable.
What the clinical study found
A 2025 study in Biomedicines evaluated AngE's forefoot pulse-volume recording in patients with diabetic foot syndrome, including those with falsely elevated ABI (≥1.3):
- The Maximum Systolic Amplitude (MSA) reached an AUC of up to 0.90, out-performing conventional indices.
- In patients with falsely elevated ABI, MSA detected PAD with 96.8% sensitivity and 87.5% specificity — finding disease the ABI missed.
- MSA values improved after revascularisation, suggesting it can also track response to treatment.
The authors concluded that quantitative forefoot PVR with AngE is a valuable tool for detecting PAD in the diabetic foot — particularly where ABI is unreliable.
What it means in practice
AngE makes PAD screening fast, painless, and feasible outside specialist vascular labs — in clinics, diabetic-care settings, and community screening. It's especially useful for people with diabetes, whose foot circulation needs watching and in whom the usual test can mislead. It sits alongside CityMedic's other preventive tools across AI diagnostics and point-of-care testing, complementing checks like our cholesterol assessment.
The honest limits
AngE is a screening and monitoring tool — diagnosis and treatment decisions remain with a doctor, and abnormal results should prompt proper vascular assessment. The figures above come from the diabetic-foot study cited below; performance in other settings continues to be studied.
Source: Nützel R, et al. Segmental Pulse Volume Recordings at the Forefoot Level as a Valuable Diagnostic Tool for Detection of Peripheral Arterial Disease in the Diabetic Foot Syndrome. Biomedicines 2025; 13(6): 1281 (doi.org/10.3390/biomedicines13061281). Product details from SOT Medical Systems. Educational summary, not medical advice.
Frequently asked questions
What is AngE by SOT Medical?
AngE is a non-invasive vascular diagnostic system from SOT Medical Systems (Austria), used to screen for peripheral artery disease and circulation problems. It measures ankle and toe pressures, pulse volume, and optical pulse signals — typically in about a minute. CityMedic distributes it in Malaysia.
What is peripheral artery disease (PAD)?
PAD is the narrowing of the arteries that supply the legs, usually from atherosclerosis. It can cause leg pain on walking, slow-healing wounds, and — especially in people with diabetes — serious foot complications. It's often silent in its early stages.
Why can the standard ABI test miss PAD in people with diabetes?
Diabetes can cause the leg arteries to stiffen and calcify (medial arterial calcification), which makes the ankle-brachial index read falsely normal or high — masking real disease. AngE's pulse-volume reading at the forefoot can detect PAD even in those cases.
Is the test painful or invasive?
No. It uses soft inflatable cuffs and optical sensors on the skin — no needles, no radiation — and is quick enough to be delegated to a nurse or technician.